Hypoxic stress is known to induce depression, cognitive dysfunction and anxiety-related
complications through the activation of oxidative and inflammatory signaling pathways. Thus,
inhibition of these pathways might ...
Arsenic, a class 1 carcinogen, is a major contaminant in drinking water globally. When
ingested by humans and animals, it contributes to tissue damage through the mechanisms
of oxidative stress and inflammation. Search ...
The opening of the mitochondrial Permeability Transition (mPT) pore is an important event
in mitochondrial-mediated cell death. Plumbagin, the active principle in Plumbago zeylanica,
induces cell death in rapidly ...
Artemisinin-based Combination Therapy (ACT) is among the best chemotherapeutic
options for malaria. Artesunate (AS) + Amodiaquine (AQ) is a commonly used ACT in
Nigeria, having good efficacy but with side effects ...
Hypertension is a major risk factor for cardiovascular diseases. Most antihypertensive drugs have been reported to effectively reduce blood pressure (BP), but they do not ameliorate end-organ damage associated with ...
The External Granular Layer (EGL) of the cerebellar cortex is a region of proliferative cells which migrate to their last position in the internal granular cell layer of the cerebellum. Delay in the transit of cells from ...
Striga hermonthica (SH) is a parasitic weed that attacks and significantly reduces the
yield of maize in Africa. The genetic interactions responsible for resistance or
susceptibility of hosts to the parasite and the ...
Lipids are essential in pregnancy homeostasis. Their reduction is associated with reduced birth
weight a major predisposing factor to diseases in adulthood. Citrus limon (lemon) Juice (CLJ) is
used in folkloric medicine ...
Iodineisessentialforthyroidhormonesynthesis.Excessiveconsumptionof
goitrogenicfoodslikesoybeans(GlycinemaxLinnaeus)andcassava(Manihot
esculenta Crantz)which are staple foods in WestAfrica can resultin
hypothyroidism.I ...
Diabetes mellitus is a disorder with episodes of hyperglycaemia. Although, Parquetina
nigrescens has been reported to reduce blood glucose, the mechanisms of its
normoglycaemic effect have not been fully elucidated. ...
Hepatitis C virus (HCV) infection results in liver cirrhosis, hepatic failure or hepatocellular carcinoma (HCC). The virus exhibits extreme sequence variability, which has resulted in emergence of variants that are distributed ...
Human Immunodeficiency Virus (HIV) is characterized by high genetic diversity which affects diagnosis, transmission, disease progression, vaccine design, co-receptor usage, response to antiretroviral therapy and development ...
Human Respiratory Syncytial Virus (HRSV) is the most common viral cause of acute lower respiratory tract infections in infants and young children,however, effective vaccine is yet to be licensed for human use till date. ...
Genital Human Papillomavirus (HPV) infection is a well-established causative agent of cervical cancer; a major cancer in most developing countries.Persistent infection with high-risk HPV, especially types 16 and 18 have ...
In Nigeria, the concentration of arsenic in ground water, which is the major source of drinking
water, is high. Arsenic causes male reproductive dysfunction by inducing oxidative stress.
Parquetina nigrescens leaf, ...
Anxiety is described as a threat to psychological, physiological and behavioral state, while depression is a potentially life-threatening disorder that presents with decreased mood.Folkloric use of Artocarpus altilis ...
Diarrhoea is a disease characterised by gut smooth muscle dysfunction associated with increased motility. Anacardium occidentale (Ao) stem bark possesses strong anti-diarrhoeal effect; however the mechanism of this effect ...
Consumption of Oryza glaberrima (Nigerian brown rice) varieties has increased over the years due to its good nutritional values. Unlike polished rice which lacks bran and has been documented to possess ulcerogenic activities, ...
Infertility is a prevalent health condition and 50% of its prevalence is related to male factor. Exposure to testicular toxicants such as Alcohol (A) and Nicotine (N) contributes to male infertility via induction of oxidative ...
Hypertension is a chronic cardiovascular disease characterised by persistent, elevated arterial blood pressure. High cost and adverse effect burden of current antihypertensive therapies necessitate the need for alternative ...